Histaminergic neurons in the brain are more active during wakefulness and slow their firing pattern as we rest or sleep. Modafinil may affect the histaminergic pathway, which deals with wakefulness and the delicate immune response of the body. In addition, this has been shown to cause adverse skin reactions that required hospitalization since the histamine pathway also deals with our immune system. Modafinil’s “beneficial” side effects may come from this heightened histaminergic neuronal activation, but too much activation can cause apoptosis, or cell death. Nootropics, like truBrain’s cognitive blend, and a few other products on the market, have dose-toxicity levels … Read the rest